People with type 2 diabetes significantly reduced elevated blood sugar levels in 12 weeks, through the Patient Experience Program (PEP), which was designed to evaluate nutritional supplementation with Diachrome™, a combination of chromium picolinate and biotin. PEP, created by Nutrition 21, Purchase, NY, enrolled patients through independent diabetes educators across the U.S. All subjects had elevated glycosylated hemoglobin (HbA1c) levels above the American Diabetes Association’s (ADA) recommendation of 7% or less, despite consumption of oral hypoglycemic agents (OHAs) for at least six months prior. HbA1c is a marker of longterm blood sugar control. Thirty subjects were provided educational materials, glucose monitors and Diachrome nutritional supplements, which they took daily while continuing their prescription medications. Each subject recorded his or her individual compliance and daily blood sugar test results. After 12 weeks, there was a significant reduction of 1.1 in average HbA1c levels. Eighteen of PEP participants who had baseline HbA1c levels above 8%, showed a decrease of 1.8, which represented a greater than average reduction.